If you’re a user of NextBio Basic, you’re probably aware that NextBio lets you access thousands of gene expression studies from sources such as GEO. NextBio has done the heavy lifting of importing, normalizing, and curating publicly available genomic data so that biologists can ask and answer biological questions completely in silico—even with little computational expertise.
Which makes our recent updates very exciting: We’ve made data from GWAS, CNV studies, and more freely available* through the NextBio Public site. These numbers update on a near-daily basis. Because our curators tag each imported study using a controlled vocabulary and custom disease ontology, you’ll easily be able to perform meta-analyses of multiple studies across different diseases through a simple, web-based interface.
Correlating genomic data from thousands of studies linked to different diseases, compounds, tissues, cells and more is complicated. We’re constantly trying to make the job a little easier, which is why we’ve also given the NextBio Public user interface a major overhaul.
If you haven’t already, check out our first blog quiz. Though the contest is closed, you’re still welcome to guess the answers! For the curious, the correct answers are included here.
Though we’d announced multiple prizes, only one entrant got all the right answers: Congratulations (once again) Dave Schlesinger!
1. The Translational Genomics Research Institute
4. Sepandar Kamvar
5. No one knows
6. All of them
Back for more excitement? We hope you’ve been following us closely, because this blog now has contests (with Rules, even), prizes and now, a quiz!
All these answers are on the blog. Think you can find them? Take our quiz and find out! All participants’ names will be entered in a drawing for one of three gift cards from Starbucks, Amazon or iTunes (your choice!). Entries must be received by August 19, 2011 to be eligible for prizes.
Congratulations to our Week 1 winners David, Yogesh and Zev! We are excited that all of you joined us and threw your names in the hat. If you’re new to this, read more about our contests and the official rules here. And come back soon for next week’s chance to win!
If you haven’t entered our contests already, there’s still time (We’ll even wait for you to finish reading the Rules first). We’ve extended our first contest deadline to August 10, 2011, so if you haven’t already, join the NextBio community now!
Finding the links between type 2 diabetes and Alzheimer’s disease
Alzheimer’s disease (AD) has been called the diabetes of the brain, with good reason. Researchers have shown that the memory loss and dementia characteristic of AD is caused by molecular disturbances in the nervous system that mimic the changes in other cells in type 2 diabetes mellitus (T2DM).
Two recent papers in the journal Cell now make another connection between the two diseases (Read more about previous connections here and here). Identifying a new role for a group of enzymes called histone deacetylases (HDACs), researchers have found a molecular pathway by which class II HDACs respond to insulin and glucagon to control blood glucose levels in mice, humans, and flies.