Tag Archives: melanoma



Shedding light on genomic signatures of melanoma

A new study shows different mutation classes associated with distinct melanoma sub-types

Skin cancer remains one of the most common forms of the disease in the U.S. Though melanomas account for less than 5% of all skin cancers, they cause the large majority of deaths from the disease. Some parts of the skin (like the palms and soles) develop cancers much less frequently, and the rare ‘acral melanomas’ that originate from these types of skin have less in common with other skin cancers. Read more…

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Nicer with Dicer? Not always.

Increases in Dicer gene expression improve some cancers and worsen others

Some of the tiniest players on the field, microRNAs (miRNAs) are short strands of RNA that work to control gene expression in several pathways. Though they don’t encode any proteins, miRNAs regulate genes involved in embryonic growth, cell differentiation, angiogenesis and other cellular processes. They have also gained steady prominence in cancer research, with several studies connecting abnormal miRNA regulation to cancer progression and metastasis in cell lines, animal models and samples from patients.

The potential diagnostic and therapeutic value of miRNAs has also turned attention to the molecules involved in making miRNAs in cells, particularly the enzyme Dicer. A recent study by Zhihai Ma and colleagues in PLoS One reports that higher Dicer expression correlates to more advanced stages of cutaneous melanoma, characterized by increased metastatic potential, tumor mitotic index, and other stages (as defined by the American Joint Committee on Cancer) .
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